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Research Interests:
My main research interest is protein secretion in prokaryotes. These systems, primarily the general or Sec-dependent system, are crucial for the survival of all prokaryotes. They function at the interface between the cell and the environment. They are required to assemble and maintain extracytoplasmic structures and allow the cell to acquire nutrients. In pathogens, whose environments are their hosts, secretion systems contribute to the survival of the pahtogen in the host and cause a variety of toxic and immunological reactions by secreting virulence factors.
Components of the general secretory complex are used to study phylogenetic and evolutionary relationships amongst the prokaryotes. The nature of secreted factors could also allude to the environmental adaptations of these organisms.
Select Publications:
Voros, A., A. Dunnett, L.G. Leduc, and M.T. Saleh. In press. Depleting proteins from the growth medium of Mycoplasma capricola unmasks bacterium-derived enzymatic activities. Vet. Microbiol.
Saleh, M., C. Song, S. Nasserulla, and L.G. Leduc. 2008. Indicators from Archaeal Secretomes. Microbiol. Res. (DOI:10.1016/j.micres.2008.03.002).
Song, C., A. Kumar, and M.T. Saleh. In press. Bioinformatic comparison of bacterial secretomes. Genom. Prot. Bioinform.
Saleh, M.T. and S. Mojumdar. In press. Thermal properties of biostimulant-infused potato fibers. J. Therm. Anal. Calorim.
Elliott, C., Z. Ye, S. Mojumdar, and M.T. Saleh. 2007. Characterization of insoluble potato fiber: A potential bacterial carrier for bioremediation. J. Therm. Anal. Calorim. 90: 707-711.
Rathore, H.S., G. Varshney, S.C. Mojumdar, and M.T. Saleh. 2007. Synthesis, characterization and fungicidal activity of zinc diethyldithiocarbamate and phosphate. J. Therm. Anal. Calorim. 90: 681-686.
Saleh, M.T., S.C. Mojumdar, and M. Lamoureux. 2006. Colorimetric determination of iron with 1,8-naphthalenediol. Res. J. Chem. Environ. 10: 14-17.
M.L. Conrad, J.E. Enman, S.J. Scales, H. Zhang, C.M. Vogels, M.T. Saleh, A. Decken and S.A. Westcott. 2005. Synthesis, characterization, and cytotoxicities of platinum(II) complexes bearing pyridinecarboxaldimines containing bulky aromatic groups. Inorg. Chim. Acta. 358: 63-69.
Mojumdar, S.C., Madgurambal, G., and M.T. Saleh. 2005. A study on synthesis and thermal, spectral and biological properties of Carboxylato-Mg(II) and Carboxylato-Cu(II) complexes with bioactive ligands. J. Therm. Anal. Cal. 81: 205-210.
Hanni A. Darwish, Stephen J. Scales, Jennifer L. Horton, Liliya G. Nikolcheva, Haiwen Zhang, Christopher M. Vogels, Mazen T. Saleh, Robert J. Ireland, Andreas Decken, and Stephen A. Westcott. 2004. Platinum pyridinecarboxaldimine complexes containing boronate esters. Can. J. Chem. 82: 1692-1699.
Stephen J. Scales, Haiwen Zhang, Paul A. Chapman, Ciara P. McRory,Eric J. Derrah, Christopher M. Vogels, Mazen T. Saleh, Andreas Decken, Stephen A. Westcott. 2004. Synthesis, characterization, and cytotoxicities of palladium(II) and platinum(II) complexes containing fluorinated Pyridinecarboxaldimines. Polyhedron 23: 2169-2176.
Mazen T. Saleh, Manuel Fillon, Patrick J. Brennan, and John T. Belisle. 2001. Prediction of putative exported/secreted proteins in prokaryotic proteomes. Gene 269: 195-204.
Mazen T. Saleh, and John T. Belisle. 2000. Secretion of an acid phosphatase (SapM) by Mycobacterium tuberculosis that is similar to eukaryotic acid phosphatases. J. Bacteriol. 182: 6850-6853. |