Chemistry, pharmaceutical option

WORKSHEET FOR STUDENTS ENROLLED IN SPECIALIZED PROGRAM IN CHEMISTRY – Option in Pharmaceutical Chemistry

 

For more information about the Chemistry program - pharmaceutical option, please contact the program counselor:  Dr. Hélène Joly, Dr. Gustavo Arteca or Dr. Joy Gray-Munro

  

Year I

Year II

Term I

Term II

Term I

Term II

CHMI 1006

(CHMI 1007 or CHMI 2117)

CHMI 2426

CHMI 2427

PHYS 1006 or 1206

PHYS 1007 or 1207

CHMI 2516

CHMI 2517

MATH 1036

MATH 1037 or

MATH 1057

E2

CHMI 2117

 or E

BIOL 1506

BIOL 1507

E2

CHMI 2227

Elective

Elective

E2

STAT 2246

 

Year III

Year IV

Term I

Term II

Term I

Term II

CHMI 3416

E3M

CHMI 4615

CHMI 3226

E3M

E4

E4

CHMI 3116

E3

E4

Elective

Elective

E3

PHIL 2345 or JURI 1105

Elective

E3

Elective

Elective

 

Students enrolled in the specialized program in Chemistry (Pharmaceutical Option) obtaining a minimum of 80 % CHMI 1006 may take CHMI 2117 instead of CHMI 1007.

‡Students having already taken CHMI 2117 in lieu of CHMI 1007 may take an elective.

 

ELECTIVE CREDITS:  Humanities or Social Sciences (12 cr)

 

TOTAL NUMBER OF CREDITS = 120

MINIMUM NUMBER OF CHMI CREDITS = 51 (students with 80 % in CHMI 1006 and taking CHMI 2117 in lieu of CHMI 1007) and 54 for others.

 

E = 17 x 3 = 51 elective credits for students having taken CHMI 1007.

E= 18 x 3 = 54 elective credits for students having taken CHMI 2117 in lieu of CHMI 1007. 

 

             

Course Descriptions

 

CHMI 1006 E - General Chemistry I

An introduction to the fundamental principles of chemistry. Topics include: atomic and molecular structure, nuclear chemistry, stoichiometry, the periodic table and periodicity, and the properties of solutions.

PREREQ: OAC or U level chemistry or CHMI 1041 or department’s permission.

(lec 3, tut 1, lab 2) cr 3

 

CHMI 1007 E - General Chemistry II

Part 2 of CHMI 1006. Topics include: thermochemistry, chemical thermodynamics, kinetics, chemical equilibrium, acid-base chemistry, buffer solutions, electrochemistry and introductory organic chemistry.

PREREQ: CHMI 1006 or 1041 (min. 80%).

(lec 3, tut 1, lab 3) cr 3

 

CHMI 2117 E - Introductory Quantitative Analysis

Examines the theory and techniques of classical quantitative analysis, including gravimetry and precipitation titrations, volumetric analysis, oxidation-reduction titrations, complexometric titrations, as well as the treatment of data. Introductorynotions of instrumental techniques are presented.

PREREQ: CHMI 1006 and CHMI 1007. Students registered in the Specialized Program in Chemistry with an average of at least 80% in CHMI 1006 may take CHMI 2117 in lieu of CHMI 1007. (lec 3, lab 3) cr 3

 

CHMI 2227 E - Biochemistry I

Topics include: protein structure and function, nucleic acid chemistry, DNA and its replication, the genetic code and protein synthesis, regulation of gene expression, cloning and gene isolation, DNA sequencing and enzyme kinetics.

PREREQ: CHMI 2426 or 2425, plus CHMI 2427 (may be taken concurrently). Students may not retain credit for both CHMI 2216 & 2227. (lec 3, lab 3) cr 3

 

CHMI 2426 E - Organic Chemistry I

An introduction to organic chemistry. Topics include: structure and bonding, nomenclature, stereochemistry, and an introduction to the chemistry of a few classes of organic compounds.

Students may not retain credit for both CHMI 2425 & 2426/7. PREREQ: CHMI 1006/7. (lec 3, lab 3, tut 1) cr 3

 

CHMI 2427 E - Organic Chemistry II

Includes a detailed investigation of the reactions of hydrocarbons and monofunctional organic compounds. The factors which affect these reactions are also discussed.

 Students may not retain credit for both CHMI 2425 & 2426/7. PREREQ: CHMI 2426.

(lec 3, lab 3, tut 1) cr 3

 

CHMI 2516 E - Introductory Physical Chemistry I

An introduction to the principles of chemical thermodynamics including the first, second and third laws of thermodynamics and the relations of thermodynamic functions to chemical equilibria in the ideal and nonideal solid, liquid and gaseous states.

Includes elementary applications of the phase rule.

PREREQ: CHMI 1006/7 & MATH 1036/7. (lec 3, lab 3, tut 1) cr 3

 

CHMI 2517 E - Introductory Physical Chemistry II

An introduction to the physico-chemical principles of electrochemistry, chemical kinetics, surface and colloid chemistry.

PREREQ: CHMI 1006/7 & MATH 1036/7. (lec 3, lab 3, tut 1) cr 3

 

CHMI 3116 E - Instrumental Techniques in Chemical, Biochemical and Environmental Sciences

The course presents the principles and components of modern instruments currently used in chemical, biological, biochemical and environmental sciences, including forensic and pharmaceutical sciences to measure and characterize elements, ions, small and large molecules and compounds. It covers the main divisions of instrumental analysis based on: 1) separation techniques such as gas, liquid and supercritical chromatography, electrophoresis, gel permeation/filtration; 2) spectroscopy, spectrometry

and optical phenomena such as ultra-violet, visible, infra-red, luminescence and fluorescence techniques, atomic spectrometry, surface plasmon resonance, X-ray techniques, radioactivity measurements, mass spectrometry; and 3) electrochemical methods based on potentiometry, voltammetry and biosensors. The interfacing of instruments (hyphenated techniques) is also covered and numerous applications are presented.

PREREQ: CHMI 2117. (lec 3, lab 3) cr 3

 

CHMI 3226 - Biochemistry II

Topics include: intermediary metabolism of carbohydrates, lipids, and amino acids; regulation of metabolism; membrane structure and functions; transmembrane signalling and potosynthesis.

PREREQ: CHMI 2227 & CHMI 2427 or 2425. Students may not retain credit for both CHMI 3217 & 3226. (lec 3, lab 3) cr 3

 

CHMI 3416 E - Intermediate Organic Chemistry

Involves the application of spectroscopic methods (N.M.R., U.V., I.R. and mass spectrometry) to the determination of structures of organic compounds, and examines the chemistry of aromatic compounds including phenols, arylhalides and polynuclear

hydrocarbons.

PREREQ: CHMI 2425 or 2427. (lec 3, lab 3) cr 3

 

CHMI 4615 E - Research and Seminar

The 4th-year student is required to carry out a research project under the supervision of a staff member chosen by the student. The research project is written as a B.Sc. thesis according to the format available from the Department of Chemistry and Biochemistry. The student must give a seminar on the topic of her/his choice in the 2nd term.

PREREQ: successful completion of 3rd year or instructor’s permission. (lab 9 min., sem 1) cr 6

 

Course options for E2 and E3

 (18 credits)

 

BIOL 2105 E - Human Anatomy and Physiology

Describes human anatomy and physiology at the cellular, tissue, organ and system levels of organization.  Concentrates on the clinical applications of anaotmy and physiology.

Students cannot take both BIOL 2105 and any BIOL 1700, 2107, 2701, PHED 1506/7 or 2106.  (lec 3, lab 3) cr 6.

 

BIOL 2111 E - Principles of Microbiology*

An introduction to microbiology (offered to students of Nursing).  The topics covered include morphology and structure, classification, microbiology techniques, microbial nutrition, growth, environmental effects on microbes, mutation and genetic recombination, sterilization and disinfetion, and antimicrobial chemotherapeutic agents.

PREREQ: grade 12U-level biology or equiv.  Students cannot take both BIOL 2111 and 2110.  *Students cannot retain credits in both BIOL 2111 and BIOL 3025.  (lec 3, lab 3)  cr 3.

 

BIOL 3025 E - Microbiology*

Examines the classification, morphology and structure, physiology and genetics of microorganisms, with emphasis upon the bacteria.  Considers the ecology of infectous diseases and environmental and applied microbiology.

PREREQ: a 1st year BIOL course. *Students cannot retain credits in both BIOL 2111 and BIOL 3025.  (lec 3, lab 3) cr 6.

 

BIOL 3117 E - Infectious Diseases

Covers the principles of medical microbiology; resistance and immunity; and infectious diseases of the genitourinary tract, respiratory tract, digestive tract and skin.  For each disease, causative agent, symptomology, chemotherapy and the possibility of immunization are considered.

PREREQ:  BIOL 2111 or 3025 (may be taken concurrently).  Students cannot take both BIOL 3117 and 2110.  (lec 3, lab 3) cr 3.

 

BIOL 3346 Ethnobotany

Examines the importance of plants and their products to the health of humandkind.  Special attention is given to plant substances of pharmacological interest, including medicinal drugs derived from roots, bark, leaves and flowers.  The importance of plants as agents of illness and disease (including allergies and favism) will also be discussed.

PREREQ: BIOL 1506 and 1507; CHMI 1202 or 2427.  (lec 3, exp/sem 3) cr 3.

 

BIOL 3726 E - Introduction  to Animal Histology

A study of the microscopy; morphology of cells and tissues in selected organs, primarily mammalian; histotechniques.

PREREQ: BIOL 2105, 2705 or 2716, 2727, or instructuor's permission.  (lec 3, lab 3) cr 3.

 

PSYC 2606 E - Brain and Behaviour

An introduction to the general relationships between human brain and human behaviour.  Human behaviour, including sleep, dreams, memory, thought, motivation, and emotion are discussed in terms of brain structure, chemistry and electrical activity.  Both known facts and realistic possibilities of brain function are considered.  Some emphasis is placed on the contribution of psychological (and social) factors to brain structure, physiology, and human disease.  A general introduction to psychopharmacology is offered.

Prior high school courses in biology and chemistry are helpful.  PREREQ: PSYC 1105 or 1st year science course (preferably chemistry or biology). (lec 3, lab 3) cr 3.

 

PSYC 2617 E - Human Neuropsychology

Examines normal behavioural and psychological correlates of the human brain.  Pathological behaviours following trauma to different brain regions are discussed.  Special emphasis is placed on the neurological aspects of psychosis, epilepsy, genetic disorders, and demyelinating diseases.  Diagnotic tests, simple neurological evaluations, and phylo-genetic comparisons of brain function are considered. 

The student is expected to have a fair understanding of brain nomenclature.  PREREQ: PSYC 2606.  (lec 2, lab 1) cr 3.

 

PSYC 3506 E - Neuropharmacology

A detailed description and evaluation of drugs that influence human behaviour. Although the greatest emphasis is upon the biochemical mechanisms and psychological effects of drugs used within clinical settings, all major pharmacological classes are covered.  Since prediction of drug effects requires an understanding of chemical pathways and their location within the human brain, the student should have a basic understanding of chemistry and neuroanatomy.

PREREQ: PSYC 2606 and 2617, dept.'s permission. (lec 3) cr 3.

 

 

Course options for E3M and E4

 (15 credits)

CHMI 3446 E– Chemical Pharmacognosy

This course will introduce students to pharmacognosy, the study of plant-derived medicinal products. In particular, several categories of natural products will be described, including the isolation of promising compounds, their structural modification for

improved properties, and the characterization of their pharmacology. Finally, the design of clinical trials and strategies for drug commercialization will be reviewed.

PREREQ: CHMI 2427 (lec 3) cr 3

 

CHMI 3257 – Principles of Pharmacology

Students will study various concepts dealing with how the body interacts with drugs. The following topics will be discussed: the routes of administration for drugs based on their physico-chemical properties; the basic concepts of pharmacokinetics and pharmacodynamics, distribution, metabolism and elimination; the mechanism of action of drugs on the central nervous, cardiovascular, renal, gastrointestinal, immune and respiratory systems; toxicology of drugs.

Prerequisite: CHMI 3226 and CHMI 3416.( Lec 3) cr 3.

CHMI 3547 F - Principes de spectroscopie et modélisation moléculaire

CHMI 4287 E - Biochemical Toxicology

Examines the biochemical principles and cellular and molecular mechanisms that contribute to the manifestation of toxicity caused by drugs and environmental chemicals with emphasis on potential routes of uptake, the enzymes which catalyze biotransformation of xenobiotics, storage and elimination. The chemical reactivity; enzymatic induction and inhibition, the role

of the cytochrome P-450-dependent mixed-function oxidase system in the deactivation and bioactivation of xenobiotics and glutathione conjugation are also presented. Topics include: reproductive toxicology and teratology, developmental toxicology, carcinogenesis, genotoxicity and mutagenesis, immunotoxicology, neurotoxicology, environmental toxicology, clinical and regulatory toxicology, human health and ecotoxicological risk assessments. Selected classes of compounds and their exposure routes, mechanisms of toxicity, fate, toxicologic sequelae and their antidotes are considered in depth.

PREREQ: CHMI 3226. (lec 3) cr 3

 

CHMI 4446 E– Drug Design and Development

This course will describe how medicinal compounds are discovered from diverse sources. It will cover the molecular modifications, using organic chemistry as a tool, in order to optimize the molecular structure to overcome undesired pharmacokinetic and pharmacodynamic properties. A detailed description of modern methods of chiral synthesis utilized to selectively produce an enantiomeric entity will be provided. A review of the methods used to resolve racemic mixtures will also be covered.

(lec 3) cr3

 

CHMI 4496 E - Physical Organic Chemistry

The kinetic and non-kinetic methods of determining the mechanisms of organic reactions are discussed in detail. Structure reactivity relationships and the effects of solvent and other physical parameters on the rates and mechanisms of reactions are also investigated. PREREQ: CHMI 3416. (lec 3) cr 3

 

CHMI 4497 E - Natural Products Chemistry

The biosynthesis and biological activity of several classes of natural products such as polyketides and terpenes will be studied. In addition, the metabolites from the shikimic acid pathway, from amino acids and from mixed biosynthetic origin will be discussed. Examples of metabolites important in chemical ecology are included.

PREREQ: CHMI 3417 or permission from instructor. (lec 3) cr 3

 

CHMI 4597 E - Computer-aided Molecular Simulations and Chemical Design

Examines, in detail, theoretical approaches to chemical reactivity, computer-aided molecular modeling and drug design, and molecular dynamics simulations. Special emphasis is placed on computer simulations of liquids, solid-gas adsorption, drug receptor interaction, protein folding, and the computation of thermodynamic properties by using statistical mechanics and molecular dynamics. Computer experiments form an essential part of the course.

Students may not retain credit for both CHMI 4597 & 5537. PREREQ: CHMI 3537.

(lec 3) cr 3

 

 

Course Offered By Other Departments that are Included in the Chemistry Program

 

Biology 1506 E - Biology I

An introductory course that addresses selected topics in biology as applied to prokaryotes and eukaryotes.  Cell biology, genetics, respiration, photosynthesis, evolution and ecology are discussed.

Students without grade 12 U-level chemistry must take CHMI 1041 concurrently.  (lec 3, lab 3) cr 3.

 

Biology 1507 E - Biology II

A study of higher plants and animals with special emphasis on structure and function.  Botanical topics include plant anatomy, reproduction, water relations, mineral nutrition, and control of growth and developemnt.  The zoological component includes the anatomy and physiology of animal tissues, organs and systems, and their functional intergration. 

(lec 3, lab 3) cr 3.

 

JURI 1105 E - Introduction to Legal Studies

An introduction to the basic concepts needed to undertake a critical study of law and the legal system.  Topics include: the nature and function of law, legal reasonning, the origins and fundamental principles of Canadian common and civil law systems and the relationship of law to other disciplines such as economics, history, philosophy and sociology.

Students may not retain credit for both JURI 1205 and 1105. (lec 3) cr 6.

 

MATH 1036 E - Calculus I
A problem-solving course which includes an extensive treatment of differential calculus and an introduction to integral calculus. Topics include: limits, continuity, differentiation, standard functions, Taylor polynomial approximation, indeterminate forms and Hospital’s rules, and practical applications. The course concludes with summation, integration, techniques of integration and the calculation of areas and volumes.
PREREQ: grade 12
4U calculus, MATH 1912 or equiv. (min. 60%). (lec 3, tut 1) cr 3

 

MATH 1037 E - Calculus II 
Begins with further techniques of integration, approximate integration, improper integrals and techniques for solving some simple first order differential equations. This is followed by parametric and polar curves, and calculations of arc length, surface area and volume. Sequences, series, power series and Taylor series are then introduced. The course concludes with elementary aspects of functions of several variables.
PREREQ: MATH 1036. 
(lec 3, tut 1) cr 3

 

MATH 1057 E - Linear Algebra I 
Topics include: simultaneous linear equations, matrices and determinants, vector spaces and linear transformations, eigenvalues and eigenvectors, applications to analytic geometry and complex numbers.
PREREQ: grade 12 4U finite mathematics or algebra, or MATH 1911, or equiv.
(lec 3) cr 3.

PHIL 2345 E - Bioethics: Human Life Issues

Examines current controversies about the benefits and dangers to human life arising from recent developments in the biomedical sciences.  Special attention is given to issues in the reproductive technologies, genetics, the care of the terminally ill, AIDS, research with human subjects, and to questions of abortion and euthanasia.  Comprehensive understanding of the issues at stake and ability to evaluate the positions taken in these controversies define the aims of the course.

Students may not retain credit for both PHIL 2345 and RLST 2345.  (lec 3) cr 6.

 

PHYS 1006 - Introductory Physics I

An introductory physics course for students who have taken OAC/U level physics. Knowledge of mechanics, vectors, and energy is assumed. The course begins with a brief review of these topics. There are three main sections: properties of matter, heat and thermodynamics, and waves.

 

PHYS 1206 - Concepts in Physics I

No prerequisite. The material covered includes the OAC material necessary to study PHYS 1007 in 2nd term. The topics covered are classical mechanics, thermodynamics, and waves. No credit for students who already have OAC/U level credit in physics (or equiv.). 

 

PHYS 1007 - Introductory Physics II

An introductory physics course for students who have taken the OAC physics course or equivalent. Knowledge of mechanics, vectors and energy is assumed. There are three main sections: geometrical optics, electricity and modern physics.

PREREQ: OAC/U level physics;(lec 3) cr 3. 

 

PHYS 1207 - Concepts in Physics II

Description not available.  Contact the Department of Physics and Astronomy.

 

STAT 2246 E - Statistics for Science
The organization of data, discrete dstributions (binominal, Poisson), continuous distributions (uniform, normal, and skewed) andlinear combinations of variables are studied.  The techniques of hypothesis testing and interval estimation are applied to problems involving means, variances, proportions, frequency tables, regression and correlation.  Students are introduced to the use of statistical computer software. 
Students may only retain credit for one MATH 2261, MATH 2236, MATH 2246 or ENGR 2017.  PREREQ: MATH 1036. 
(lec 3, tut 1) cr 3.


 
 
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