Current Position

• Canada Research Chair in Biomolecular Science
• Director, Biomolecular Sciences Programme
• Department of Chemistry and Biochemistry
• Department of Biology
• Medical Sciences Division

Education and Training

Current Position

• Canada Research Chair in Biomolecular Science
• Biomolecular Sciences Programme Director
• Faculty, Department of Chemistry and Biochemistry
• Cross-appointment, Department of Biology

Education and Training

1997-2002 Assistant Professor of Medicine
Faculty, Division of Cardiovascular Disease and Critical Care Medicine and Department of Immunology/Microbiology
Rush-Presbyterian-St. Luke's Medical Center and University
Chicago, IL, USA

1995-1997 Research Fellow
Cleveland Clinic Foundation, Dept. of Molecular Biology
Cleveland, OH, USA

1992-1997 Ph.D. University of Toronto, Faculty of Medicine
Dept. of Molecular and Medical Genetics
Toronto, Ontario, Canada

1990-1992 M.Sc. University of Toronto, Faculty of Medicine
Dept. of Molecular and Medical Genetics
Toronto, Ontario, Canada

1983-1988 B.Sc. Honours, University of Toronto, Faculty of Arts and Science Specialist Programme in Molecular Genetics and Biology Major Programme in Human Biology, Minor Programme in Physiology
Toronto, Ontario, Canada

Awards and Honours

2004 Ontario Distinguished Researcher Award

2004 Laurentian University Faculty Award, "The Role that Bacterial DNA and RNA Play During Sepsis"

1996 Cleveland Clinic Foundation, Lower Award [for original research paper] "The Jak/Stat Pathway is Required for Cytokine Induced Programmed Cell Death" Second Place

1995 International Society for Interferon and Cytokine Research, Young Investigator
Award, First Place

1995 Cleveland Clinic Foundation, Lower Award [for original research paper] "Deficient Cytokine Signaling in Pkr0/0 MEFs", First Place

1994 Cleveland Clinic Foundation, Young Investigator Award, Second Place

1984 Gold Duke of Edinburgh's Award (presented by the Duke of Edinburgh)

Research Funding

• Canada Research Chairs
• Canadian Institutes of Health Research
• Ontario Research and Development Challenge Fund
• Canada Foundation for Innovation
• Ontario Innovation Trust
• Northern Mines and Development
• Laurentian University Institutional Research Funds

Lab Staff

Research Investigations

Identification and Characterization of Sepsis Molecular Signalling Pathways

Sepsis and septic shock represent the overwhelming response to infection. Approximately 800,000 cases of sepsis are admitted every year to hospitals in the North America and despite aggressive antibiotics and supportive care, over 200,000 patients per year succumb to this disorder. Sepsis and sepsis-associated multiple organ failure are the leading cause of death in intensive care units of the developed world and claim over 500,000 lives per year world wide. We are characterizing new initiators and mediators of sepsis and septic shock. These pathways and process include: cytokine signalling, transcription factor modulation, apoptosis, bacterial DNA and RNA signalling and characterization of global gene expression patterns that occur during the disease. To examine these signalling events we have developed a tissue culture model and a mouse model of sepsis and septic shock. We are also studying tissues from spontaneous human sepsis and septic shock.

Research Projects:

1. Cytokine and transcription factor regulation: We are identifying infecting organism(s), cytokine profile (including IFNs, ILs and TNFs) and transcription factor profile (including STAT, IRF and NF-?B) in our models of sepsis. We are currently determining if modulation of these cytokines and transcription factors during the disease will increase viability.
2. Apoptosis: We have shown that apoptosis occurs during sepsis and septic shock with an increase in caspase gene expression and activation. We are characterizing caspase gene family expression and are employing inhibitors of caspase activation as a drug therapy.
3. Bacterial DNA and RNA: We have determined that bacterial DNA and RNA induce a depression of myocyte contraction. Regulation of the pathways involved in bacterial DNA and RNA dependent myocyte depression may lead to novel therapeutics.
4. Global gene expression: We have determined that genes involved in the pro-inflammatory response, cell adhesion molecule regulation, apoptosis and cell cycle control are modulated during sepsis. We are using rationale drug design to alter deleterious gene expression patterns that occur during sepsis and septic shock.

Selected Publications

Refereed Papers

Lisa Falvo, Paul Michael, Danielle Brabant, Marisa Tessier, Marija Tonnos, Xiulong Xu, Chilakamarti V. Ramana, Richard Enelow, Rama Kota, Amadeo M. Parissenti, Abdelwahab Omri, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Human Septic Serum Induced Apoptotic Gene Expression Profile in Human Myocytes. In Press, Nova Science 2007.

Anand Kumar, Bhanu Paladugu, Joel Mensing, Aseem Kumar and Joseph E. Parrillo.  Nitric Oxide-Dependent and -Independent Mechanisms are Involved in TNF-a-Induced Depression of Cardiac Myocyte Contractility.  In press, American Journal of Physiology 2007.

Danielle Brabant, Paul Michael, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Characterization of Key Apoptotic Signalling Pathways that Mediate Sepsis Induced Cellular Dysfunction. In press, New Cell Apoptosis Research 2006.

Anand Kumar, Bhanu Paladugu, Aseem Kumar, Joel Mensing and Joseph E. Parrillo. TGF-b Blocks in-vitro Cardiac Myocyte Depression Induced by TNF-a and IL-1b and Human Septic Shock Serum. In Press, CCM J. 2006.

Anand Kumar, Kenneth E. Wood, Robert Suppes, Joseph E. Parrillo, Daniel Feinstein, Satendra Sharma, Sergio Zanotti, Leo Taiberg, David Gurka, Aseem Kumar, Mary  Cheang, Bruce Light, Daniel Roberts. Duration of Hypotension Prior to Initiation of Effective Antimicrobial Therapy is the Critical Determinant of Survival in Human Septic Shock.  In Press, CCM J. 2006.

Rama S. Kota, Kapilchandra Gohil, Aseem Kumar, Richard I. Enelow, John C. Rutledge and Chilakamarti.V. Ramana. Regulation of gene expression in RAW 264.7 macrophages by Interferon-gamma. In press, Biochemical and Biophysical Research Communications. March 2006.

Aseem Kumar, Anand Kumar, Paul Michael, Danielle Brabant, Amadeo M. Parissenti Chilakamarti V. Ramana, Xiulong Xu and Joseph E. Parrillo. Human Serum Derived from Patients with Septic Shock Activates Transcription Factors STAT1, IRF1, NF-kB and Induces Apoptosis in Human Cardiac Myocytes. In Press, J. Biol. Chem. 2005.

Anand Kumar, Bhanu Paladugu, Cameron Haery, Aseem Kumar, Simon Symeoneides, Gordon Trenholme, Joanne Sandelski, Steve Opal and Joseph E. Parrillo. Duration of Hypotention Prior to Antibiotic Administration is a Critical Determinant of Outcome in a Murine Model of E. coli Septic Shock. In press, Journal of Infectious Diseases 2005.

Chilakamarti V. Ramana, Aseem Kumar and Richard Enlow. STAT1-independent Induction of SOCS-3 by Interferon-? is Mediated by Activated STAT3 in Mouse Embryo Fibroblasts. Biochemical and Biophysical Research Communications 327:727-733, 2005.

Bhanu Paladugu, Anand Kumar, Joseph E. Parrillo, Sandy Der, Jailan Osman, Joel Mensing, Lisa Falvo, Xiulong Xu and Aseem Kumar. Bacterial DNA and RNA Induce Rat Cardiac Myocyte Contraction Depression In-Vitro. Shock Journal 21(4):364-369, April 2004.

Ping Jiang, Aseem Kumar, Joseph E. Parrillo, Laurie A. Dempsey, Jeffrey L. Platt, Richard A. Prinz, Xiulong Xu. Transcriptional regulation of heparanase 1 gene expression in thyroid neoplastic cell lines by Sp1. J. Biol. Chem. 277: 8989-8998, March 15, 2002.

Xiao Rui Li, Anita Chong, Jianming Wu, Kenneth A. Roebuck, Aseem Kumar, Joseph E. Parrillo, Ulf R. Rapp, Robert P. Kimberly, James W. Williams and Xiulong Xu. Transcriptional Regulation of Fas Gene Expression by GA Binding Protein (GABP) and AP1 in T Cell Antigen Receptor (TCR)/CD3 Complex-Stimulated T Cells. J. Biol. Chem. 274, 35203-35210, December 3, 1999.

Aseem Kumar, Mairead Commane, Thomas Flickinger, Curt Horbath, and George R. Stark. Defective TNF-?-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases. Science, 278, 1630-1632, November 28, 1997. News and Views, 1541, ibid. Perspective, 1578-1579, ibid.

Aseem Kumar, Yi-li Yang, Vincenzo Flati, Sandy Der, Suzanne Kadereit, Jaharul Haque, Amitabha Deb, Luiz Reis, Charles Weissmann and Bryan R.G. Williams. Deficient Cytokine Signalling in Mouse Embryo Fibroblasts with a Targeted Deletion in the PKR Gene. EMBO J. 16, 406-416, January 15, 1997.

Michael Rutherford, Aseem Kumar, Jaharul S. Haque and Bryan R.G. Williams. Proto-oncogene Ets-1 Specifically Binds the ISRE of 2-5A Synthetase. Journal of IFN and Cytokine Research 17, 1-10, 1997. [The first two authors contributed equally to the paper and should be considered as first co-authors]

Michael Rutherford, Aseem Kumar, Benoit Coulombe, Dan Skup, Dave Carver and Bryan R.G. Williams. Intracellular Interferon Constituitively Activates ISGF3 and Confers Resistance to EMC Viral Infection. Journal of IFN and Cytokine Research 16, 507-510, July 1996. [The first two authors contributed equally to the paper and should be considered as first co-authors]

Jaharul S. Haque, Heiko van der Kuip, Aseem Kumar, Walter E. Aulitzky, Michael N. Rutherford, Christopher Huber, Thomas Fischer, and Bryan R.G. Williams. Overexpression of Mouse p140-Subunit of Replication Factor C Accelerates Cellular Proliferation. Cell Growth and Differentiation 7,319-326, March 1996.

Yi-Li Yang, Luiz Reis, Jovin Pavlovic, Adriano Aguzzi, Reinhold Schafer, Aseem Kumar, Bryan R.G. Williams, Michel Auget and Charles Weissmann. Deficient Signalling in Mice Devoid of Double-stranded RNA-dependent Protein Kinase, PKR. EMBO J. Vol. 14, no. 24, 6095-6106, December 15, 1995.

A. Maran, R.K. Maitra, A.Kumar, B. Dong, W. Xiao, B.R.G. Williams, P.F. Torrence and R.H. Silverman. Blockage of NF-?B Signaling By Selective Ablation of an mRNA Target by 2-5A-Antisense Chimeras. Science, Vol. 265, 789-792, August 5, 1994.

Aseem Kumar, Jaharul S. Haque, Judith Lacoste, John Hiscott and Bryan R.G.Williams. The dsRNA-Dependent Protein Kinase, PKR, Activates Transcription Factor NF-?B by Phosphorylating I?B. Proc. Natl. Acad. Sci. USA, Vol. 91, 6288-6292, July 5, 1994.

Gengsheng Feng, Karen Chong, Aseem Kumar and Bryan R.G. Williams. Identification of dsRNA Binding Domains of the Interferon Induced Protein Kinase. Proc. Natl. Acad. Sci. USA, Vol. 89,5447-5451, June 1992.

Michael N. Rutherford, Aseem Kumar, Ahuva Nissim, Judith Chebath and Bryan R.G. Williams. The Murine 2-5A Synthetase Locus: Three Distinct Transcripts From Two Linked Genes. Nucleic Acids Research, Vol. 19, 1917-1924, #8, 1991.

Invited Commentaries

Kumar Anand and Kumar Aseem: Development of Sepsis Therapeutics and Molecular Diagnostics.  In Press, Expert Commentary, Nova Science 2007.

Anand Kumar and Aseem Kumar. Nitric Oxide and Inflammatory Cytokines in the Heart: The Presence of Positive Feedback Loops. In press, CCM J.

Kumar Anand, Kumar Aseem: Endotoxemic myocardial depression: A novel iNOS suppressing effect of albumin. Critical Care Medicine, 31:324-326, 2003.

Court O, Kumar Aseem, Parrillo JE, Kumar Anand: Myocardial dysfunction in the septic patient. Critical Care Medicine, 6:500-508, 2002.

Krishnagopalan S, Kumar Aseem, Parrillo JE, Kumar Anand: Myocardial dysfunction in sepsis and septic shock. Current Opinion in Critical Care, 5:376-388, 2002.

Manocha S, Feinstein D, Kumar Aseem, Kumar Anand: Experimental and emerging therapies for sepsis and septic shock: Part 3. Anti-endotoxin strategies in gram-negative sepsis and septic shock. Expert Opinion in Investigational Drugs, 11:1795-1812, 2002.

Zanotti S, Kumar Aseem, Kumar Anand: Experimental and emerging therapies for sepsis and septic shock: Part 2. Cytokine modulation in sepsis and septic shock. Expert Opinion in Investigational Drugs, 11:1061-1075, 2002.

Anand Kumar, Aseem Kumar and Joseph E. Parrillo. Reversible Myocardial Dysfunction: A Ubiquitous Phenomena in the Critically Ill? Critical Care Medicine, 30:1392-1393, 2002.

Aseem Kumar, Anand Kumar and Joseph E. Parrillo. IL-1 Gene Cluster: All in the Family. Critical Care Medicine, 30:1168-1169, 2002.

Anand Kumar, Ana Krieger, Simon Symeoneides, Aseem Kumar and Joseph E. Parrillo. Myocardial Dysfunction in Septic Shock: Part II. Roles of Cytokines and Nitric Oxide. Journal of Cardiothoracic and Vascular Anesthesia, Vol 15, No 4 (August), 2001: pp 485-511.

Anand Kumar, Aseem Kumar and Joseph E. Parrillo. Cytokines and Septic Myocardial Depression: Nitric Oxide vs. Sphingosine/Ceramide? Critical Care Medicine, 27:1391-1393, 1999.

Book Chapters

Kumar Anand, Kumar Aseem, Parrillo JE: Myocardial Dysfunction in Sepsis and Septic Shock. Acute Heart Failure Syndromes: A Practical Approach for Physicians.  Editor: Alexandre Mebazza. Springer-Verlag. In press, 2007

M. Pilar Gil, Aseem Kumar, Richard I. Enelow and Chilakamarti V. Ramana. STAT1-independent Pathways in Interferon Signaling. Interferons (editor Kailash Chadha, Roswell Park Cancer Center, Buffalo, NY) (2006)

Cornelius F. Waller,M.D., Ratan K. Maitra, Ph.D., Avudaiappan Maran, Ph.D., Aseem Kumar, M.Sc., Beihua Dong, M.Sc., Wei Xiao, Ph.D., Guiying Li, Ph.D., Bryan R.G. Williams,Ph.D., Paul F. Torrence, Ph.D. and Robert H. Silverman, Ph.D. 2-5A-Anti-sense a Novel Approach to Cancer Therapy. Biology of Renal Cell Carcinoma, Springer-Verlag, 133-148 (1995).

Paul F. Torrence, Wei Xiao, Guiying Li, Shahrzad Khamnei, Krystyna Lesiak, Avudaiappan Maran, Ratan Maitra, Aseem Kumar, Beihua Dong, Bryan R. G. Williams and Robert H. Silverman. Targeting RNA for Degradation with a (2',5')- oligoadenylate Antisense Chimera. Nucleosides and Nucleotides, 14(3-5), 1073-1076 (1995).

Conference Proceeding Reviews

Danielle Brabant, Paul Michael, Marija Tonnos, Marisa Tessier, Shuhung Kung, Anand Kumar, Chilakamarti V. Ramana and Aseem Kumar. Molecular Biology of Sepsis. Proceedings of the International Biotechnology Symposia. Haldia Institute of Technology, India, January 2005.

Chilakamarti V. Ramana, Aseem Kumar, Jyothi Chinthrapalli and Richard I. Enelow. CD8+ T Cell and Alveolar Epithelial Cell Interactions in Lung Injury. Proceedings of the International Biotechnology Symposia. Haldia Institute of Technology, India, January 2005.

Short Reports (Meeting Presentations)

Aseem Kumar, Anand Kumar, G Skorupa, M Vukonich, B Paladugu, P Narang, C. Haery, H. Merchant and J E Parrillo.Characterzation Of Intracellular Signalling Components Involved in Sepsis. Nature Biotechnology Short Reports, Volume 10: Advances in Gene Technology; Signal transduction & therapeutic strategies, 1999;10:74

Kumar Anand, Kumar Aseem, G Skorupa, Vukonich M, Paladugu B, Saleem A, Narang P, Parvathala P, R Battula, R Makkena, Haery C, And Parrillo JE. Early human septic serum-induced cardiac myocyte depression is caused by synergestic stimulation of a constitutive nitric oxide synthase by TNF-Alpha and IL-Beta Nature Biotechnology Short Reports, Volume 10: Advances in Gene Technology; Signal transduction and therapeutic strategies,1999;10:39.

Plenary Talks at International Conferences

The Role of PKR in Signal Transduction. International Society for Interferon and Cytokine Research. Baltimore, U.S.A., 1995.

A Selective Role for PKR in Interferon and Cytokine Signaling. International Society for Interferon and Cytokine Research. Genevea, Switzerland, 1996.

Defective TNF-?-induced Apoptosis in STAT1-null HT1080 Cells Due to Low Constitutive Expression of Ice-family Proteases. International Society for Interferon and Cytokine Research. San Diego, U.S.A., 1997.

Symposium Oral Presentations

Human Septic Sera Induces Death Receptor Mediated Apoptosis in Human Fibroblasts. Canadian Federation of Biological Sciences, October 2006.

Characterization of Intracellular Signalling Components Involved in Sepsis. Canadian Federation of Biological Sciences, October 2006.

Characterization of Intracellular Signalling Components Involved in Sepsis. Society of Critical Care Medicine, San Francisco, January 1999.

Transcription Factor Acitivation in Myocardial Tissue Exposed to Human Septic Serum. FASEB Meeting, Washington, D.C. April 1999.

Abstracts

Bryan R.G. Williams, Nigel McMillan and Aseem Kumar. Tumor Suppressor Activity of the Interferon Induced dsRNA Activated, Kinase, PKR. Proceedings of the Eighty-Fifth Annual Meeting of the American Association for Cancer Research.San Francisco, California, Vol. 35. March 1994.

Aseem Kumar, Jahar Haque, John Hiscott and Bryan R.G. Williams. The dsRNA-Activated p68 Kinase Regulates NF-kB via Phosphorylation of Its Inhibitor IkB. EMBL Conference Oncogenes and Growth Control, page 129, Heidelberg, Germany, April 1994.

Bryan R.G. Williams, Aseem Kumar, Bruce W. Carpick and Nigel J. Macmillan. The Role of PKR in Interferon Induction and Action. Symposium on Interferons and Interacting Cytokines: Cellular and Clinical Response and Resistance. June 1994, Litchfield, Arizona.

Aseem Kumar and Bryan R.G. Williams. The Role of PKR in DSRNA Dependent Signal Transduction. Journal of Interferon Research,Vol. 14, page S50, September 1994.

Aseem Kumar and Bryan R.G. Williams. The Role of PKR in DSRNA and Interferon Signal Transduction. The Cleveland Clinic Foundation Symposium. September 1994.

R.H. Silverman, B.A. Hassel, A. Zhou, A. Maran, R.K. Maitra, B. Dong, C. Walker, A. Kumar, B.R.G. Williams, W. Xiao, G. Li and P.F. Torence. Control of Viral and Cellular RNA Stability by the Interferon-Regulated, 2-5A-dependent RNAse. ASM Conference on the Role of RNA Decay and Processing in Biological Systems. August 1994.

Aseem Kumar and Bryan R.G. Williams. The Role of PKR in DSRNA and Interferon Signal Transduction. The Irvine H. Page-Harland G. Wood Cleveland Virology Group Symposium. October 1994.

Bryan R.G. Williams, Aseem Kumar, Charles Weissmann and Jaharul Haque. Signal Transduction Deficiencies in PKR-deleted Mouse Embryo Fibroblasts. American Cancer Research Meeting, Toronto, March 1995.

Sandip Vasavada, Raymond Rackley, Aseem Kumar, Rodney Appell and Bryan R.G. Williams. Characterization of Signal Transduction Pathways in Urothelium: A Basis for Regulating Immune and Inflammatory Responses. The Cleveland Clinic Foundation Symposium. September 1995.

Yi-li Yang, Luiz F.L. Reiss, Jovan Pavlovic, Adriano Aguzzi, Reinhold Schafer, Aseem Kumar, Bryan R.G. Williams, Michel Aguet and Charles Weissmann. Deficient Signalling in Mice Devoid of Double-stranded RNA-dependent Protein Kinase, PKR. Journal of IFN and Cytokine Research, Vol. 1, page S115, November 1995.

Aseem Kumar, Vincenzo Flati, Jaharul Haque, Amitabha Deb, Suzanne Kadereit, Luiz Reis, Yi-li Yang, Charles Weissmann and Bryan R.G. Williams. Deficient Interferon Signalling in Mouse Embryo Fibroblasts with a Targeted Deletion in the PKR Gene. Journal of IFN and Cytokine Research, Vol. 1, page S105, November 1995.

B.R.G. Williams, A. Kumar and S.D. Der. A Selective Role for PKR in Interferon and Cytokine Signaling. Symposium on Interferon Signaling at Iowa State University. page 16, June 13, 1996.

B.R.G. Williams, A. Kumar and S.D. Der. A Selective Role for PKR in Interferon and Cytokine Signaling. Journal of IFN and Cytokine Research. Geneva, Switzerland, October, 1996.

B.R.G. Williams, A. Kumar and S.D. Der. A Selective Role for PKR in Interferon and Cytokine Signaling. Joint Congress of the BSI and the Biochemical Society, Harrogate, UK. Immunology. Vol 89, Suppl. 1, November 1996.

Aseem Kumar, Mairead Commane, Thomas W. Flickinger, Curt M. Horvath, James E. Darnell, Jr. and George R. Stark. Defective TNF-a-induced Apoptosis in STAT1-null HT1080 Cells Due to Low Constitutive Expression of Ice-family Proteases. Journal of IFN and Cytokine Research. In press. October, 1997.

Steve E. Wilson, Woo-Jung Kim, Aseem Kumar, George R. Stark. Corneal Keratocyte Apoptosis is Diminished in Response to Epithelial Injury in Stat 1 -/- Mice. Second Gordon Conference on Cell Death, page PO50, June 29-July 3, 1997.

B. Prasad, M. Rozynek, E. Zarycka, M. Saleem, L. Talberg, Aseem Kumar, S. Simonydes, M. Matushek, G. Skorupa, G. Trenholme, J. E. Parrillo and Anand Kumar. A New Murine Model of E. Coli Peritonitis. Journal of Investigative Medicine, Midwestern Regional Meeting, Chicago, IL, September 1998.

M. Rozynek, M. Parmar, B. Prasad, V. Pallekonda, P. Malik, H. Krottapalli, U. Yenigalla, Aseem Kumar, J. E. Parrillo and Anand Kumar. Tumor Necrosis Factor-? (TNF-?) Impairs Catecholamine-stimulated Cardiac Mycocyte Contractility via Both Nitric Oxide-dependent and Independent Mechanisms. Journal of Investigative Medicine, Midwestern Regional Meeting, Chicago, IL, September 1998.

Aseem Kumar, Anand Kumar and Joseph E. Parrillo. Identification and Characterization of Signalling Components Involved in Sepsis. Journal of IFN and Cytokine Research. Jerusalem, Israel, October 1998.

S. Simonydes, G. Trenholme, Aseem Kumar, B. Prasad, M. Saleem, P. Narang. S. Avula, A. Aboul-Saoud, D. Lingam, G. Skorupa, M. Matushek, J. E. Parrillo and Anand Kumar. A New Murine Model of E. Coli Peritonitis and Septic Shock. Infectious Disease Society of America, Denver, Colorado, November 1998.

Anand Kumar, Aseem Kumar, E. Choudhury, M. Saleem, S. Avula, P. Parvathala, A. Aboul-Saoud, K. Surapaneni, D. Lingam, B. Prasad, G. Skorupa, Joseph E. Parrillo. Transforming Growth Factor (TGF-b) Inhibits Human Septic Serum-Induced Depression of Cardiac Myocyte Contractility. San Francisco, California, Jan. 1999.

S. Simonydes, Aseem Kumar, B. Prasad, M. Saleem, P. Narang, S. Avula, A. Aboul-Saoud, D. Lingam, G. Skorupa, M. Matuschek, R. Goldfarb, G. Trenholme, J. E. Parrillo and Anand Kumar. A Novel Murine Model of E. Coli Peritonitis Stimulates Human Septic Shock. San Francisco, California, January 1999.

Aseem Kumar, Anand Kumar, S. Simonydes, G. Skorupa, B. Paladuga, D. Lingam, A. Saleem, S. Avula, K. Sindha, A. Aboul-Saoud, K. Surapaneni, P. Narang, P. Parvathala, M. Vukonich, R. Goldfarb and J. E. Parrillo. Characterization of Intracellular Signalling Components Involved in Sepsis. Society of Critical Care Medicine, San Francisco, California, January 1999.

Anand Kumar, S. Symeoneides, Aseem Kumar, B. Prasad, M. Saleem, S. Avula, R. Makkena, R. Battula, D. Lingam, K. Sindha, G. Skorupa, M. Matuschek, R. Goldfarb, G. Trenholme and J. E. Parrillo. A Novel Murine Model of E. Coli Peritonitis Simulates Human Septic Shock. FASEB Meeting, Washington, D.C. April 1999.

Aseem Kumar, Anand Kumar, M. Vukonich, G. Skorupa, B. Paladuga, D. Lingam, A. Saleem, S. Avula, K. Sindha, A. Aboul-Saoud, K. Surapaneni, P. Narang, P. Parvathala and J. E. Parrillo. Transcription Factor Acitivation in Myocardial Tissue Exposed to Human Septic Serum. FASEB Meeting, Washington, D.C. April 1999.

C. Haery, B. Paladugu, R. Makkena, M. Vukonich, G. Skorupa, Aseem Kumar, G. Trentholme, J. E. Parrillo and Anand Kumar. Effect of Steroids on Survival and Hemodynamics in a Murine Model of Septic Shock. Chest 1999.

Vukonich, G. Skorupa, G. Trentholme, Aseem Kumar, J. E. Parrillo and Anand Kumar. Timing of Steriod Administration in Murine Septic Shock. Society of Critical Care Medicine. Orlando, Florida, February 11, 2000.

N. Jindal, B. Paladugu, C. Haery, R. Makkena, D. Patel, N. Adoni, V. Patel, M. Vukonich, G. Trentholme, Aseem Kumar, J. E. Parrillo and Anand Kumar. Antibiotics and Fluid Resuscitation in a Murine Model of Septic Shock. . Society of Critical Care Medicine. Orlando, Florida, February 11, 2000.

R. Anel, B. Paladugu, R. Makkena, C. Haery, H. Ganga, G. Skorupa, D. Patel, M. Vukonich, Aseem Kumar, J. E. Parrillo and Anand Kumar. TNFa-Induces a Proximal Defect of b-Adrenoreceptor Signal Transduction in Cardiac Myocytes. Society of Critical Care Medicine. Orlando, Florida, February 11, 2000.

Aseem Kumar, Anand Kumar, M. Vukonich, C. Haery and J. E. Parrillo. Characterization of the JAK/STAT Pathway During Sepsis. Society of Critical Care Medicine. Orlando, Florida, February 11, 2000.

Aseem Kumar, Anand Kumar and Joseph E. Parrillo. Identification of Gene Expression Patterns that Occur During Sepsis. Society of Critical Care Medicine. Orlando, Florida, February 11, 2000.

J. Osman, B. Paladugu, J. E. Parrillo, L. Taiberg, C. Haery, Aseem Kumar, E. Kassas, H. Kadakia, R. Goldfarb and Anand Kumar. Transforming Growth Factor B-1 Decreases Mortality During Murine Entotoxic Shock. Society of Critical Care Medicine. Vol. 29, Number 12, page A44, 2001.

Osman J, Taiberg L, Paladugu B, Kumar Aseem, Goldfarb R, Parrillo JE, Kumar Anand Myocardial Depression Measured with a Micro-Conductance Catheter in a Murine Model of Endotoxic Shock.Crit Care Med. 30:A70, 2002.

Taiberg L, Osman J, Paladugu B, Kumar Aseem, Goldfarb R, Parrillo JE, Kumar Anand. Transforming Growth Factor Blocks Endotoxin-Induced Myocardial Depression in Mice. Crit Care Med. 30:A55, 2002.

Kumar A., Kumar A., Paladugu B., Mensing J., Haery C., Symeoneides S., Goldfarb R., and Parrillo J.E. Duration of hypotension prior to antibiotic therapy is a critical determinant of survival in murine model of E. coli septic shock. Crit Care Med. 2004:32 (12 suppl): #507 page 143.

Danielle Brabant, Paul Michael, Marija Tonnos, Marisa Tessier, Shuhung Kung and Aseem Kumar.  Characterization of Sepsis Signalling Pathways. Laurentian University French Language Conference, January 2005.

Danielle Brabant, Paul Michael, Marija Tonnos, Marisa Tessier, Shuhung Kung, Chilakamarti V. Ramana, Joseph E. Parrillo and Anand Kumar and Aseem Kumar. Identification and Characterization of Mediators of Sepsis.  ACFAS, Montreal, Canada. March 2006.

Marisa Tessier, Paul Michael, Danielle Brabant, Marija Tonnos, Shuhung Kung, Viktoria Kekonen, Tyler Kirwan and Aseem Kumar.  Identification of Factors in Septic Sera that Cause Cellular Dysfunction.  Laurentian University French Language Conference, March 2006.

Marisa Tessier, Marija Tonnos, Paul Michael, Danielle Brabant, Shuhung Kung, Chilakamarti V. Ramana, Joseph E. Parrillo and Anand Kumar and Aseem Kumar. Gene Profiling During Sepsis. Northern Research Conference, Northern Ontario School of Medicine and Algoma University, Sault St. Marie, Ontario, Canada.  June 2006.

Shuhung Kung, Paul Michael, Marija Tonnos, Danielle Brabant, Chilakamarti V. Ramana, Joseph E. Parrillo and Anand Kumar and Aseem Kumar. The Role that Bacterial RNA and DNA Play in Mediating Myocyte Contraction Depression. Northern Research Conference, Northern Ontarion School of Medicine and Algoma University, Sault St. Marie, Ontario, Canada.  June 2006.

Danielle Brabant, Paul Michael, Marija Tonnos, Marisa Tessier, Shuhung Kung, Chilakamarti V. Ramana, Joseph E. Parrillo and Anand Kumar and Aseem Kumar. The Role that Apoptosis Plays in Mediating Sepsis Induced Myocyte Cellular Dysfunction. Northern Research Conference, Northern Ontario School of Medicine and Algoma University, Sault St. Marie, Ontario, Canada.  June 2006.

Danielle Brabant, Paul Michael, Marija Tonnos, Marisa Tessier, Shuhung Kung, Tyler Kirwan, Abdelwahab Omri, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Human Septic Sera Induces Death Receptor Mediated Apoptosis in Human Fibroblasts.  Canadian Federation of Biological Sciences, Ottawa, ON, October 2006.

Tyler Kirwan, Danielle Brabant, Paul Michael, Marissa Tessier, Marija Tonnos, ShuHung Kung, Abdelwahab Omri, Chilakamarti V. Ramana, Anand Kumar, Joseph E. Parillo and Aseem Kumar.  Characterization of Intracellular Signalling Components Involved in Sepsis. Canadian Federation of Biological Sciences, Ottawa, ON, October 2006.

Shuhung Kung, Paul Michael, Marija Tonnos, Marisa Tessier, Danielle Brabant, Tyler Kirwan, Viktoria Kekkonen, Abdelwahab Omri, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Bacterial RNA and Viral RNA Mediated Stress-induced Apoptosis Involves Double-stranded RNA Protein Kinase (PKR) Pathway. Canadian Federation of Biological Sciences, Ottawa, ON, October 2006.

Marija Tonnos, Marisa Tessier, Paul Michael, Danielle Brabant, Shuhung Kung, Tyler Kirwan, Abdelwahab Omri, Chilakamarti V. Ramana, Rama Kota, Amadeo M. Parissenti, Joseph E. Parrillo, Anand Kumar and Aseem Kumar.  Characterization of Gene Expression Profiles that Occur during Sepsis.  Canadian Federation of Biological Sciences, Ottawa, ON, October 2006.

M. Alipour, Z.E. Suntres, A. Kumar and A. Omri.  Liposomal Polymixin B: Preparation, Characterization and Evaluation of its Activity Towards Gram-negative Bacterial Strains. Canadian Association for Clinical Microbiology and Infectious Diseases. Halifax, NS. March 2007.

M. Halwani, A.O. Azghani, A. Kumar and A. Omri. Antimicrobial Activity of Encapsulated Tobramycin in Liposomal-bismuth Formulation.  Canadian Association for Clinical Microbiology and Infectious Diseases. Halifax, NS. March 2007.

Tyler Kirwan, Paul Michael, Danielle Brabant, Marija Tonnos, Shuhung Kung, Marisa Tessier, Chilakamarti V. Ramana, Abdelwahab Omri1, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Characterization of Transcription Factor Signalling Pathways in Sepsis.  Northern Health Research Conference, Northern Ontario School of Medicine and Algoma University, Sault St. Marie, Ontario, Canada.  June 2007

Danielle Brabant, Paul Michael, Marija Tonnos, Shuhung Kung, Tyler Kirwan, Marisa Tessier,  Abdelwahab Omri, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and  Aseem Kumar. Characterizing the Role that the Extrinsic and Intrinsic Apoptotic Pathways Play During Sepsis. Northern Health Research Conference, Northern Ontario School of Medicine and  Algoma University, Sault St. Marie, Ontario, Canada.  June 2007.

Shuhung Kung, Paul Michael, Marisa Tessier, Danielle Brabant, Tyler Kirwan, Marija Tonnos, Abdelwahab Omri, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Late Stage Sepsis Gene Expression Profiling.  Northern Health Research  Conference, Northern Ontario School of Medicine and Algoma University, Sault St. Marie,  Ontario, Canada.  June 2007.