Lee Stewart, Ph.D. (University of Western Ontario)
The Hospital of Sick Children, Toronto ON; Email: lee.stewart@sickkids.ca
Adjunct Professor, Psychology Department, Laurentian University
Research areas: Pediatric epilepsy. Down syndrome. Use of dietary modification and exercise to improve behavioral outcome in animal models of neurological disease.
Related Experience
July 1, 2006 to present Research Associate, Behavioral Neuroscience Program, Laurentian University, Sudbury, Ontario
Abstracts and Presentations
Han, H.A., Wu, Y., Cortez, M.A., Stewart, L.S., Velazquez, J.L.P., Shen, L., & Snead, O.C. III. Atypical absence epilepsy in mice over-expressing R1b and R2 subunits of GABAB receptor. Society for Neuroscience, 2008.
Stewart, L.S., Cortez, M.A., & Snead, O.C. III. Environmental enrichment improves behavioral outcome in a model of chronic atypical absence seizures. American Epilepsy Society, 2007 (Abst. 1.273).
Cortez, M.A., Stewart, L.S., Shen, L., Snead, O.C. III. Age-specificity in the Ts65Dn-GBL acute model of acute epileptic extensor spasms: EEG, pharmacology and behavior. American Epilepsy Society, 2007.
Snead, O.C. III, Stewart, L.S., Aleem, I., Shen, L., Ashraff, A., & Cortez, M.A. A new animal model of infantile spasms: genotypic, EEG and behavioral characterization. American Academy of Neurology, 2007.
Stewart, L.S., & Leung, L.S. Anticonvulsant activity of a melatonin receptor antagonist. Society for Neuroscience Abstracts, 2002.
McKay, B.E., Stewart, L.S., & Persinger, M.A. The putative neurotransmitter and NMDA antagonist agmatine: effects on learning and memory. Alberta Neuroscience Conference, 2002.
Book Chapters
Gupta, M., Stewart, L.S., & Gupta, Y. (2007). Understanding the role of melatonin in epilepsy: from bench to bedside. In Melatonin: From molecules to therapy. Nova Science Publishers, pp. 813-825.
Articles Published or in Press
Long, J.A., Shen, B., Luo, T., Stewart, L.S., McMurran, T., & Leung, L.S. (2009). Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. Experimental Neurology (in press).
Stewart, L.S., Persinger, M.A., Cortez, M.A., & Snead, O.C. III (2009). Behavior of Ts65Dn Down syndrome mice expressing different coat color alleles. Neuroscience Letters (in press).
Stewart, L.S., Wu, Y., Eubanks, J.H., Han, H., Leschenko, Y., Perez-Velasquez, J.L., Cortez, M.A., & Snead, O.C. III (2009). Severity of seizure phenotype in GABAB mutant mice is subtype specific. Epilepsy& Behavior (in press).
Cortez, M.A., Shen, L., Wu, Y., Aleem, I., Trepanier, C., Sadeghnia, H.R., Ashraf, A., Kanawaty, A., Liu, C.-C., Stewart, L.S., & Snead, O.C. III (2009). Infantile spasms and Down syndrome: A new animal model. Pediatric Research (in press).
Stewart, L.S., Nylen, K.J., Cortez, M.A., & Snead, O.C. III (2008). Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism. Epilepsy & Behavior, 13(2): 290.
Stewart, L.S., Persinger, M.A., Cortez, M.A., & Snead, O.C. III (2006). Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome. Behavior Genetics, 37(2): 388.
Stewart, L.S., Shukla, R., Serbanescu, I., Persad, V., Mistry, N., Nercovici, E., Cortez, M.A., & Snead, O.C. III (2006). Daily rhythms of seizure activity and behavior in a model of atypical absence epilepsy. Epilepsy & Behavior, 9: 564.
Stewart, L.S., & Stifani, S. (2005). Dendritic localization of the transcriptional co-repressor TLE1 in cortical and cerebellar neurons. Molecular Brain Research, 140(102): 106.
Stewart, L.S., & Stifani, S. (2005). Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina. Journal of Neurochemistry, 94(6): 1739.
Stewart, L.D., Leung, L.S. (2005). Hippocampal melatonin receptors module seizure threshold. Epilepsia, 46(4): 473.
Stewart, L.S., & Leung, L.S. (2002). Temporal lobe seizures alter the amplitude and timing of rat behavioral rhythms. Epilepsy & Behavior, 4(2): 153.
Ma, J., Shen, B., Stewart, L.S., Harrick, I., & Leung, L.S. (2002). The septohippocampal system participates in general anesthesia. Journal of Neuroscience, 22(RC200): 1.
Persinger, M.A., Stewart, L.S., Richards, P., O’Connor, R.P., Harrigan, T., & Bureau, Y.R.J. (2002). Seizure onset times for rats receiving systemic lithium and pilocarpine: sources of variability. Pharmacology, Biochemistry and Behavior, 71(1-2): 7.
Stewart, L.S., & Persinger, M.A. (2001). Ketamine prevents learning impairment when administered immediately after status epilepticus onset. Epilepsy & Behavior, 2(6): 585.
Stewart, L.S. (2001). Endogenous melatonin and epileptogenesis: facts and hypothesis. International Journal of Neuroscience, 107(1-2): 77.
Stewart, L.S., Leung, L.S., & Persinger, M.A. (2001). Diurnal variation in pilocarpine-induced tonic-clinic generalized seizure activity. Epilepsy Research, 44(2-3): 207.
Stewart, L.S., & McKay, B.E. (2000). Acquisition deficit and temporally-graded retrograde amnesia for contextual fear conditioning in agmatine treated rats. Behavioural Pharmacology, 11(1): 93.
Stewart, L.S. (2000). Differential effects of a physiologically patterned low-intensity agent on the formation of an olfactory memory trace. International Journal of Neuroscience, 103(1-4): 19.
Stewart, L.S. & Persinger, M.A. (1999). Pretraining exposure to physiologically patterned electromagnetic stimulation attenuates fear-conditioned analgesia. International Journal of Neuroscience, 100(1-4): 91.