Examines the biochemical principles and cellular and molecular mechanisms that contribute to the manifestation of toxicity caused by drugs and environmental chemicals with emphasis on potential routes of uptake, the enzymes which catalyze biotransformation of xenobiotics, storage and elimination. The chemical reactivity, enzymatic induction and inhibition, the role of the cytochrome P-450-dependent mixed-function oxidase system in the deactivation and bioactivation of xenobiotics and glutathione conjugation are also presented. Topics include: reproductive toxicology and teratology, developmental toxicology, carcinogenesis, genotoxicity and mutagenesis, immunotoxiocology, neurotoxicology, environmental toxicology, clinical and regulatory toxicology, human health and ecotoxicological risk assessments. Selected classes of compounds and their exposure routes, mechanisms of toxicity, fate, toxicologic sequelae and their antidotes are considered in depth. PREREQ: CHMI 3226. (lec 3) cr 3