This course will explore advanced concepts of medicinal chemistry. The mechanisms of drug action and pharmacokinetic principles will be discussed in detail. This will be followed by a discussion of the strategies in drug design with special emphasis on combinatorial chemistry and related topics. The course will also include a discussion of the classes and the mode of action of drugs acting on the CNS and drugs stimulating the peripheral NS. Students may not retain credit for both CHMI 5486 and CHMI 4486. (lec 3) cr 3.